Bradycardia produced by pyridostigmine and physostigmine

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Bradycardia produced by pyridostigmine and physostigmine.

PURPOSE The bradycardia produced by pyridostigmine and physostigmine in an animal model of acute cardiac denervation was examined according to its relation to cholinesterase inhibition and sensitivity to block by cholinergic receptor antagonists. METHODS Cats were anaesthetised, vagotomised and propranolol-treated. Heart rate was continuously recorded. Erythrocyte cholinesterase activity of a...

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Success of pyridostigmine, physostigmine, eptastigmine and phosphotriesterase treatments in acute sarin intoxication.

The acute toxicity of organophosphorus (OP) compounds in mammals is due to their irreversible inhibition of acetylcholinesterase (AChE) in the nervous system, which leads to increased synaptic acetylcholine levels. The protective actions of intravenously (i.v.) administered pyridostigmine, physostigmine, eptastigmine, and an organophosphate hydrolase, phosphotriesterase, in acute sarin intoxica...

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On the Mechanism of Bradycardia Produced by Strospeside in Cats.

安孫子 保 The work was supported by a grant from the Ministry of Education in Japan. In spite of numerous reports on bradycardia produced by cardiac glycosides hitherto , the mechanism is not completely clarified. Ackermann (1) reported that early digitalis bradycardia was prevented by vagal severance or by administration of atropine. This observation has generally been ac cepted. Heymans and Heyma...

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Bradycardia, hypotension and bronchospasm following remifentanil-propofol in a myathenic paitent treated by pyridostigmine--a case report.

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ژورنال

عنوان ژورنال: Canadian Journal of Anaesthesia

سال: 1997

ISSN: 0832-610X,1496-8975

DOI: 10.1007/bf03012778